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Symptomatic knee osteoarthritis (OA) can be viewed as the end result of a molecular cascade which ensues after certain triggers occur and ultimately results in irreversible damage to the articular cartilage. The clinical phenotype that knee OA can produce is variable and often difficult to accurately predict. This is further complicated by the often poor relationship between radiographic OA and knee pain. As a consequence, it can be difficult to compare studies that use different definitions of OA. However, the literature suggests that while there are multiple causes of knee OA, two have attracted particular attention over recent years; occupation related knee OA and OA subsequent to previous knee injury. The evidence of a relationship, and the strength of this association, is discussed in this chapter.

Original publication

DOI

10.1016/j.berh.2015.05.005

Type

Journal article

Journal

Best Pract Res Clin Rheumatol

Publication Date

06/2015

Volume

29

Pages

454 - 461

Keywords

Activity, Biomarkers, Injury, Knee, Occupation, Osteoarthritis, Female, Humans, Knee Injuries, Male, Musculoskeletal Pain, Occupational Diseases, Occupational Exposure, Osteoarthritis, Knee, Pain Management, Sex Factors